P08.04.B The Clinical Frailty Scale is superior to the Karnofsky Performance Status as predictor of overall survival in patients with surgical treatment of brain metastases

Abstract Background The Clinical Frailty Scale (CFS) evaluates patients’ level of frailty on a scale from 1 (very fit) to 9 (terminally ill) and is commonly used in geriatric medicine, intensive care orthopaedics but not patients harboring neuro-oncological diseases. Our study was conducted reveal if the usage CFS generates more reliable prediction overall survival after brain metastases resection rather than Karnofsky Performance Status (KPS). Material Methods All which were operated for metastatic disease at our department 2005-2019 included. KPS retrospectively assessed timepoints pre- postoperatively as well during follow-up 3-6 months resection. Results 205 with mean 22.8 (CI95% 18.4-27.1) evaluated. Mean estimated OS 32.1 25.0-39.1). showed median 3 points (IqR 2-4) all assessment-points means “managing well”. Median 80 preoperative 80-90) 90 80-100) postoperative months. strongly correlated KPS: preoperatively (r=-0.92; p< 0.001), (r=-0.85; p<0.001) (r=-0.93; p<0.001). In same time, only weak correlation (r=0.30, p<0.001; r=0.37, p<0.001, correspondingly). multivariate integrated Cox regression model, predicted expected reduction superior assessment-points. One point increase represented 30% additional hazard decease (HR=1.30, CI95% 1.15-1.46; p<0.001), correspondingly provides 39% (HR=1.39, 1.25-1.54; 42% (HR= 1.42, 1.27-1.59; case KPS, decrease 10 resulted hazards 26% (HR=0.974/point, 0.962-0.987; 14% (HR=0.986/point, 0.978-0.993; 31% (HR=0.969/point, 0.959-0.978; follow-up. Conclusion feasible performance scoring undergoing metastasis resection, that better compared KPS. Whereas, specifies most accurately. Due between vs. months, initial does predict score.